Technology
How It Works
Striving to Treat Blinding Retinal Conditions
Intravitreal injection of ROX solution through pars plana for treating Central Retinal Artery Occlusion
![](https://m83c22.p3cdn1.secureserver.net/wp-content/uploads/2023/10/treat-retinal-diagram-1360x680-1.jpg?time=1722036717)
The Science
![](https://m83c22.p3cdn1.secureserver.net/wp-content/uploads/2022/08/science-diagram-680x680-1.jpg?time=1722036717)
Schematic of the conceptualized Oxygen nanobubble.
![](https://m83c22.p3cdn1.secureserver.net/wp-content/uploads/2023/10/science-diagram-680x680-2.jpg?time=1722036717)
Transmission Electron Microscopic image of a single oxygen encapsulated nanodelivery system.
Clinical Applications
Publications and Patents
Publications:
- Fayyaz M, Jabeen M, Tsipursky MS, Irudayaraj J. Dextran-based oxygen nanobubbles for treating inner retinal hypoxia. ACS Nano. 2021;4(7):6583-6593. doi: 10.1021/acsanm.1c00084
- Bhandari P, Novikova G, Goergen CJ, Irudayaraj J. Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep. 2018;8(1):3112. doi:10.1038/s41598-018-20363-8
- Bhandari P, Wang X, Irudayaraj J. Oxygen Nanobubble Tracking by Light Scattering in Single Cells and Tissues. ACS Nano. 2017;11(3):2682-2688. doi:10.1021/acsnano.6b07478
- Bhandari PN, Cui Y, Elzey BD, Goergen CJ, Long CM, Irudayaraj J. Oxygen nanobubbles revert hypoxia by methylation programming. Sci Rep. 2017;7(1):9268. doi:10.1038/s41598-017-08988-7
- Liu W, Mohan SP, Nagaraj NR, et al. Epigenetic alterations associated with dexamethasone sodium phosphate through DNMT and TET in RPE cells. Mol Vis. 2021;27:643-655.
- Aloysius Dhivya M, Aberami S, Nikhalashree S, et al. Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells. Biochim Biophys Acta Mol Basis Dis. 2020;1866(10):165843. doi:10.1016/j.bbadis.2020.165843
Patents:
- Nanobubbles, US Patent 10,670,581 [Irudayaraj and Bhandari] (2020)
- Nanobubbles, US9968692B2 [Irudayaraj and Bhandari] (2018)
- UIUC2020-110-01(PRO) – 500.124PRV – Provisional Patent Application “Polysaccharide encapsulated oxygen nanobubbles”