Technology

How It Works

Striving to Treat Blinding Retinal Conditions

Intravitreal injection of R_OX solution through pars plana for treating Central Retinal Artery Occlusion

The Science

Schematic of the conceptualized Oxygen nanobubble.

Transmission Electron Microscopic image of a single oxygen encapsulated nanodelivery system.

Clinical Applications

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Publications and Patents

Publications:

• Fayyaz M, Jabeen M, Tsipursky MS, Irudayaraj J. Dextran-based oxygen nanobubbles for treating inner retinal hypoxia. ACS Nano. 2021;4(7):6583-6593. doi: 10.1021/acsanm.1c00084
• Bhandari P, Novikova G, Goergen CJ, Irudayaraj J. Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep. 2018;8(1):3112. doi:10.1038/s41598-018-20363-8
• Bhandari P, Wang X, Irudayaraj J. Oxygen Nanobubble Tracking by Light Scattering in Single Cells and Tissues. ACS Nano. 2017;11(3):2682-2688. doi:10.1021/acsnano.6b07478
• Bhandari PN, Cui Y, Elzey BD, Goergen CJ, Long CM, Irudayaraj J. Oxygen nanobubbles revert hypoxia by methylation programming. Sci Rep. 2017;7(1):9268. doi:10.1038/s41598-017-08988-7
• Liu W, Mohan SP, Nagaraj NR, et al. Epigenetic alterations associated with dexamethasone sodium phosphate through DNMT and TET in RPE cells. Mol Vis. 2021;27:643-655.
• Aloysius Dhivya M, Aberami S, Nikhalashree S, et al. Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells. Biochim Biophys Acta Mol Basis Dis. 2020;1866(10):165843. doi:10.1016/j.bbadis.2020.165843

Patents:

• Nanobubbles, US Patent 10,670,581 [Irudayaraj and Bhandari] (2020)
• Nanobubbles, US9968692B2 [Irudayaraj and Bhandari] (2018)
• UIUC2020-110-01(PRO) – 500.124PRV – Provisional Patent Application “Polysaccharide encapsulated oxygen nanobubbles”