TECHNOLOGY
How it works
Striving to treat blinding retinal conditions

Intravitreal injection of ROX solution through pars plana for treating Central Retinal Artery Occlusion
Striving to treat blinding retinal conditions

Intravitreal injection of ROX solution through pars plana for treating Central Retinal Artery Occlusion
THE SCIENCE
THE SCIENCE

Schematic of the conceptualized Oxygen nanobubble.
Transmission Electron Microscopic image of a single oxygen encapsulated nanodelivery system.
PUBLICATIONS AND PATENTS
Publications:
a) Fayyaz, M., Jabeen, M., Tsipursky, M., and Irudayaraj, J. 2021. Dextran-based oxygen nano-bubbles for treating inner retinal hypoxia. ACS Applied Nano Materials 2021 Jul 6.
b) Bhandari P., Novikova G, Goergen, C., and Irudayaraj, J. 2018. Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Nature Scientific Reports, 8(1):3112.
c) Bhandari, P., Wang, X., and Irudayaraj, J. 2017. Oxygen Nanobubble Tracking by Light Scat-tering in Single Cells and Tissues. ACS Nano. 11(3): 2682-2688.
d) Bhandari, P., Cui, Y., Long, C., Elzey, B., Goergen, C., and Irudayaraj, J. 2017. Oxygen nano-bubbles revert hypoxia by methylation programming. Nature Scientific Reports. 7(1):9268
e) Liu, W., Ramasubramanyan, S., Mohan, S., Nagaraj, N., Jaganathan, S., and Wen, Y., and Irudayaraj, J. 2021 Epigenetic alterations associated with Dexamethasone sodium phosphate through DNMT and TET in retinal pigment epithelium cells. Molecular Vision (In Press).
f) M Aloysius Dhivya; S Aberami; S Nikhala Shree; J Biswas, MD; Wenjie Liu; Joseph Irudayaraj; K N Sulochana; Karunakaran Coral; Bharathi devi. 2020. Copper mediates mitochondrial biogenesis in Retinal pigment epithelial cells. Biochimica et Biophysica Acta – Molecular Basis of Disease. 1866(1):165843.
Patents:
a) Nanobubbles, US Patent 10,670,581 [Irudayaraj and Bhandari] (2020)
b) Nanobubbles, US9968692B2 [Irudayaraj and Bhandari] (2018)
c) UIUC2020-110-01(PRO) – 500.124PRV – Provisional Patent Application “Polysaccharide encapsulated oxygen nanobubbles”